Allergies Home > Xyzal

By blocking the effects of histamine, Xyzal can help relieve chronic hives and allergy symptoms (including sneezing, runny nose, and itchy eyes). This prescription medication comes in tablet and liquid form and is typically taken once a day. Dosing will vary, based on factors such as your age and other medical conditions you may have. Side effects of Xyzal include drowsiness, fatigue, and dry mouth.

What Is Xyzal?

Xyzal® (levocetirizine dihydrochloride) is a prescription antihistamine medication that is approved to treat the following conditions:
  • Allergies, including seasonal allergies and allergies that occur all year long (known as perennial allergies)
  • Chronic hives due to unknown causes (known medically as chronic idiopathic urticaria).
(Click Xyzal Uses for more information, including possible off-label uses.)

Who Makes Xyzal?

Brand-name Xyzal is made jointly by UCB, Inc., and sanofi-aventis.

How Does It Work?

Allergies occur when the body's immune system reacts to normally harmless substances that do not bother most people. This reaction is partly caused by the release of histamine from certain cells in the body. Xyzal is an antihistamine, which means it blocks histamine from binding to histamine receptors and causing allergy symptoms. Because histamine is responsible for many of the symptoms of allergies, blocking it can be helpful.
Histamine is also responsible for the formation of hives. By blocking histamine, Xyzal can alleviate the itching due to hives.


Xyzal has been evaluated in several different studies for treating allergies. In these studies, the drug helped reduce allergy symptoms, including sneezing, a runny nose, and itchy nose and eyes. These studies also showed that Xyzal begins to work quickly, usually by the second day of treatment.
Xyzal has also been studied for treating chronic hives and rashes that are due to unknown causes. In these studies, people who took Xyzal had fewer and smaller hives and experienced less itching, compared to people who took a placebo (a "sugar pill" with no active ingredient).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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