Allergies Home > Lastacaft

A healthcare provider may prescribe Lastacaft to relieve eye allergies. This medication is specifically designed to treat eye itching caused by allergies and works by blocking certain histamine receptors in the body. It comes in the form of an eye drop and is typically used in each eye once daily. Side effects may include eye burning, redness, or stinging.

What Is Lastacaft?

Lastacaft™ (alcaftadine) is a prescription eye drop approved for treating eye itching caused by allergies. It is used just once a day.
(Click Lastacaft Uses for more information on this topic, including possible off-label uses.)

Who Makes This Medication?

Lastacaft is manufactured by Vistakon Pharmaceuticals, LLC.

How Does Lastacaft Work?

Lastacaft belongs to a class of drugs known as H1 receptor antagonists, commonly known as antihistamines. It works by blocking a specific type of histamine receptor in the body known as H1 receptors. Because allergic reactions are partly caused by the release of histamine from certain cells in the body, Lastacaft can help relieve or prevent allergy symptoms.
In addition to blocking histamine receptors, Lastacaft may decrease the release of histamine from cells in the body.

Clinical Effects

In clinical studies, Lastacaft was shown to relieve itching of the eyes due to allergies. The studies showed that Lastacaft was more effective than a placebo eye drop (the same formulation, but without the active ingredient) for relieving eye itching.
These studies showed that Lastacaft was effective within 3 minutes and lasted as long as 16 hours after a dose.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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