Zyrtec-D Drug Interactions

A few of the medications that Zyrtec-D can potentially interact with include selegiline, digoxin, and phenelzine. Drug interactions with Zyrtec-D can cause your body to metabolize the drugs differently than intended and cause some drugs to become less effective, among other things. Be sure to talk with your pharmacist or healthcare provider about Zyrtec-D drug interactions that may apply to you.

An Overview of Zyrtec-D Drug Interactions

Zyrtec-D® (cetirizine and pseudoephedrine) can potentially interact with a few other medications. Some of the medicines that may lead to Zyrtec-D drug interactions include:
 
 
  • Stimulants, such as cocaine, amphetamines, and many attention deficit hyperactivity disorder (ADHD) medications.
     

Zyrtec-D Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Zyrtec-D is combined with any of the drugs listed above.
 
 
Blood Pressure Medications
Zyrtec-D may make blood pressure medications less effective, possibly causing high blood pressure (hypertension). This is due to the pseudoephedrine component of the drug. If you take high blood pressure medications, check with your healthcare provider before taking Zyrtec-D or try plain Zyrtec® instead, which does not contain pseudoephedrine and does not increase blood pressure.

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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