Sudafed Drug Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when
Sudafed is combined with any of the drugs listed above.
Bromocriptine
Combining
bromocriptine with Sudafed may increase the risk of serious problems such as
high blood pressure, an irregular heart rhythm (arrhythmia), or
seizures. If you take bromocriptine, check with your healthcare provider before taking Sudafed.
Cannabinoids
Taking Sudafed with a cannabinoid drug increases the risk of a rapid heart rate (tachycardia), which can be dangerous. It is probably best to avoid combining Sudafed with a cannabinoid, unless your healthcare provider recommends otherwise.
Carbonic Anhydrase Inhibitors
Carbonic anhydrase inhibitor medications may increase the level of Sudafed in the blood (by decreasing its excretion through the urine). This may increase the risk of
Sudafed side effects. If you take a carbonic anhydrase inhibitor, check with your healthcare provider before taking Sudafed.
Iobenguane I 123
Sudafed may interfere with tests that use iobenguane I 123. You should not take Sudafed for several days before a laboratory test that involves iobenguane I 123 (your healthcare provider will give you more specific instructions).
Monoamine Oxidase Inhibitors (MAOIs)
Taking Sudafed and an MAOI together can cause life-threatening problems. Never take Sudafed with an MAOI or even within two weeks of taking an MAOI.
Phenothiazines
Sudafed may increase the risk of a dangerous irregular heart rhythm (arrhythmia) due to a phenothiazine medication. If you are on a phenothiazine medication, check with your healthcare provider before taking Sudafed.
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