Drugs That Interfere With Oxymetazoline Nasal Spray

Oxymetazoline Nasal Spray Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when oxymetazoline nasal spray is combined with any of the drugs listed above.
Taking oxymetazoline nasal spray with a cannabinoid drug increases the risk of a rapid heart rate (tachycardia), which can be dangerous. If you notice a rapid heart rate while taking oxymetazoline nasal spray (with or without a cannabinoid), it is probably best to stop taking it.
Iobenguane I 123
Oxymetazoline nasal spray may interfere with tests that use iobenguane I 123. You should not take oxymetazoline nasal spray for several days before a laboratory test that involves iobenguane I 123 (your healthcare provider will give you more specific instructions).
Monoamine Oxidase Inhibitors (MAOIs)
If a significant amount of oxymetazoline (the active ingredient in the nasal spray) is absorbed into the bloodstream, it is possible that combining oxymetazoline nasal spray and an MAOI could cause life-threatening problems. If you are on an MAOI, make sure to check with your healthcare provider before using this nasal spray. Often, it is recommended to avoid oxymetazoline nasal spray while taking an MAOI or even within 14 days of taking an MAOI.
Tricyclic Antidepressants
Tricyclic antidepressants could increase the risk of high blood pressure due to oxymetazoline nasal spray. This is most likely to happen if a significant amount of the nasal spray is absorbed into the bloodstream, which might occur if the spray runs down the back of the throat and is swallowed. If you take a tricyclic antidepressant, check with your healthcare provider before using the nasal spray.
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