Allergies Home > Benadryl Drug Interactions

When Benadryl is taken with anticholinergic drugs, monoamine oxidase inhibitors, or phenothiazine medications, drug interactions may occur. These interactions could increase your risk of developing certain side effects, such as dry mouth, constipation, dry eyes, or difficulty passing urine. Other medications that may cause drug interactions with Benadryl include acetylcholinesterase inhibitors, pramlintide, and medicines that cause drowsiness.

Benadryl Interactions: An Overview

Benadryl® (diphenhydramine hydrochloride) can potentially interact with a number of other medications. Some of the medicines that may lead to drug interactions with Benadryl include (but are not limited to):
 
  • Alcohol
  • Acetylcholinesterase inhibitor medications, including:

 

 

  • Anticholinergic drugs, such as:

 

 

  • Monoamine oxidase inhibitors (MAOIs), including:

 

 

  • Other medications that cause drowsiness, including, but not limited to:

 

 

  • Phenothiazine medications, including:

 

 

Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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