Karbinal ER Warnings and Precautions

To ensure safe treatment with Karbinal ER, there are certain warnings and precautions for those who have asthma, heart disease, and certain other medical conditions. Your healthcare provider can help review safety concerns that may apply to your particular situation. Not everyone can take this drug. For example, women who are breastfeeding and children younger than age two should avoid Karbinal ER.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Karbinal™ ER (carbinoxamine extended-release oral suspension) if you have:
Also, let your healthcare provider know if you:
  • Drink alcohol
  • Are pregnant or thinking of becoming pregnant
  • Are breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings for Karbinal ER

Some warnings and precautions to be aware of prior to taking this medicine include the following:
  • There have been reports of deaths occurring in children under the age of two who took medicines containing carbinoxamine (the active ingredient in Karbinal ER). Therefore, Karbinal ER should not be given to children who are younger than two years old.
  • Karbinal ER can cause significant drowsiness, which could affect your reflexes and reaction times. Do not drive, operate heavy machinery, or perform any activities that require mental alertness while taking this medicine. Alcohol and other medications that cause drowsiness may add to these effects and should not be used with Karbinal ER.
  • This medication could worsen certain medical conditions, such as:
    • Conditions that cause increased pressure within the eye, such as glaucoma
    • Hyperthyroidism (an overactive thyroid)
    • Heart disease
    • High blood pressure
    • Stomach ulcers
    • Prostatic hypertrophy (an enlarged prostate)
    • Certain bladder problems that make it difficult to urinate (urinary bladder-neck obstruction)
    • A blockage of the lower part of the stomach (pyloroduodenal obstruction).
  • Karbinal ER contains a sulfite, which may cause serious allergic-type reactions in people who are sensitive to sulfites (this is not the same as having a "sulfa" allergy, which is an allergy to sulfonamide medications). The reactions can range from a life-threatening reaction known as anaphylaxis to mild asthma attacks. Although an allergy to sulfites is generally considered to be rare, it may be more common in people with asthma.
  • Each Karbinal ER dose should be measured with an accurately marked measuring device, such as an oral syringe, medicine cup, or medicine spoon. A regular household spoon should not be used, as it is not accurate enough and could lead to an overdose. Your pharmacist can provide you with an appropriate measuring device and can show you how to correctly measure the dose.
  • Karbinal ER is a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are currently unknown (see Karbinal ER and Pregnancy)
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Karbinal ER Medication Information

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