Treatment Info for Hydrocodone Polistirex/Chlorpheniramine Polistirex

How Does Hydrocodone Polistirex/Chlorpheniramine Polistirex Work?

Hydrocodone polistirex/chlorpheniramine polistirex contains two different medicines:
  • Hydrocodone -- a semi-synthetic narcotic cough suppressant
  • Chlorpheniramine -- an antihistamine.
Hydrocodone acts in a similar way as codeine. It is thought to work in the "cough center" of the brain, where it helps reduce the urge to cough.
Chlorpheniramine blocks a specific type of histamine receptor in the body, known as H1 receptors. Allergy symptoms, such as a runny nose, sneezing, and watery eyes, are partly caused by histamine binding to these receptors. By preventing histamine from binding to H1 receptors, chlorpheniramine helps relieve or prevent allergy symptoms.
Chlorpheniramine also blocks acetylcholine receptors, an action that produces some of the unpleasant side effects of the medication, such as dry mouth. However, blocking these specific receptors also helps to relieve a runny nose.
Hydrocodone polistirex/chlorpheniramine polistirex is an extended-release product, which means the medication is slowly released into the body. As a result, the medication works for a longer time and does not need to be taken as often to help relieve allergy and cold symptoms.

When and How to Take This Medication

Some general considerations to keep in mind during treatment with hydrocodone polistirex/chlorpheniramine polistirex include the following:
  • This medication comes in liquid form. It is taken by mouth twice a day, with about 12 hours between doses.
  • You can take hydrocodone polistirex/chlorpheniramine polistirex with food or on an empty stomach. Try taking this medication with food if it upsets your stomach.
  • Shake the bottle well before each use.
  • Make sure you measure hydrocodone polistirex/chlorpheniramine polistirex with an oral syringe, medicine cup, or accurately marked measuring spoon. Do not use a household spoon to dose this medication. Household spoons are not accurate enough, and you might take too much or too little. Your pharmacist can give you an appropriate measuring device.
  • Do not mix hydrocodone polistirex/chlorpheniramine polistirex with other liquids or medicines. This may cause all of the medication to be released into the body too quickly and increase the chance of side effects.
  • For the medication to work properly, it must be taken as prescribed.
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Hydrocodone Polistirex/Chlorpheniramine Polistirex Drug Information

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