Dymista Drug Interactions

Dymista Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Dymista is combined with any of the drugs listed above.
CYP 3A4 Inhibitors
The liver breaks down the fluticasone component of Dymista using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining Dymista with one of these drugs may increase the level of fluticasone in your bloodstream, increasing your risk for side effects. This is an important and potentially serious interaction, even for fluticasone in the form of a nasal spray (such as Dymista). Some CYP 3A4 inhibitors have a larger effect than others. Check with your healthcare provider before combining Dymista with a CYP 3A4 inhibitor.
The prescribing information specifically warns against combining Dymista with ritonavir, which is a particularly strong CYP 3A4 inhibitor, stating that this combination is not recommended.
Medications That Cause Drowsiness
Azelastine (the antihistamine in Dymista) can sometimes cause drowsiness. Combining Dymista with other medications that can cause drowsiness may lead to additive effects, perhaps decreasing mental alertness and interfering with your ability to operate a vehicle or heavy machinery.

Final Thoughts

It is possible that not all Dymista drug interactions were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about the specific interactions that may apply to you.
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