• There are certain medications that Clarinex-D can interact with (see Clarinex-D Drug Interactions).
   
• Although Clarinex-D causes drowsiness less often than other antihistamines, it can still make some people tired. Therefore, until you know whether Clarinex-D makes you tired, caution should be used before driving a car or operating potentially dangerous machinery.
   
• Clarinex-D is a pregnancy Category C medicine, meaning that it could potentially harm your unborn child. If you are pregnant, you should only take Clarinex-D if the benefit outweighs the possible risk to your unborn child. Discuss this with your healthcare provider before using the drug.
   
• If you are nursing or plan to nurse, Clarinex-D passes through your milk. Therefore, if you are taking Clarinex-D and nursing, it is recommended that you stop until talking with your doctor.
   

• You are allergic to Clarinex-D, desloratadine, Claritin, loratadine, pseudoephedrine, adrenergic agents, or any of the inactive components used in making Clarinex-D. Your healthcare provider or pharmacist has a list of the inactive ingredients.
   
• You have narrow-angle glaucoma.
   
• You have urinary blockage or difficulty urinating.
   
• You are taking an MAO inhibitor or have taken an MAO inhibitor within the last 14 days. MAO inhibitors are medicines used to treat depression. Some examples of MAO inhibitors include:

o Isocarboxazid (Marplan^®)

o Phenelzine (Nardil^®)

o Selegiline (Eldepryl^®, EMSAM^®)

o Tranylcypromine (Parnate^®)

• You have severe high blood pressure (hypertension).

 

• You have severe coronary heart disease.