Drugs That Can Interfere With Benadryl

Benadryl Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Benadryl is combined with any of the drugs listed above.
 
Alcohol
You should avoid alcohol while taking Benadryl, as undesirable side effects (such as excessive drowsiness, dizziness, or confusion) may result.
 
Acetylcholinesterase Inhibitor Medications
Taking Benadryl with an acetylcholinesterase inhibitor can make both medications less effective. Your healthcare provider may need to monitor you more closely and adjust your dose of these medications to prevent interactions from occurring. Check with your healthcare provider before combining these medications.
 
Anticholinergic Drugs
Combining an anticholinergic medication with Benadryl (which is also an anticholinergic medication) can increase your risk of Benadryl side effects, such as dry mouth, constipation, dry eyes, or difficulty passing urine. Check with your healthcare provider before combining these medications.
 
Monoamine Oxidase Inhibitors (MAOIs)
Taking Benadryl and an MAOI together can prolong and intensify certain side effects of Benadryl (such as drowsiness, dry mouth, constipation, dry eyes, or difficulty passing urine). Check with your healthcare provider before combining these medications.
 
Other Medications That Cause Drowsiness
Check with your healthcare provider before combining Benadryl with any other medication that also causes drowsiness, as undesirable side effects (such as excessive drowsiness, dizziness, or confusion) may result.
 
Phenothiazines
It is possible that Benadryl may increase the risk of a dangerous irregular heart rhythm (arrhythmia) due to a phenothiazine medication. Additionally, combining Benadryl with a phenothiazine increases the risk of excessive drowsiness.
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