Allegra-D

Allegra-D is a combination medicine that is commonly prescribed to treat hay fever. The medicine, which is part antihistamine and part decongestant, has proven to be effective in relieving allergy symptoms such as sneezing, runny nose, nasal congestion, and itchy nose or throat. Allegra-D comes in a tablet form and is available in several strengths, including 12-hour and 24-hour formulas.

 

What Is Allegra-D?

Allegra-D® (fexofenadine and pseudoephedrine) is a prescription medication that is used to treat seasonal allergies (hay fever).
 
Allegra-D is manufactured by Sanofi-Aventis Pharmaceuticals.
 
(Click Allegra-D Uses for more information on its uses.)
 

How Does Allegra-D Work?

When you come in contact with something you're allergic to, a chain reaction begins inside your body. During this chain reaction, special cells release powerful chemicals. Some of these chemicals can trigger swelling of the nasal passages, leading to nasal congestion (a "stuffy nose"). Other chemicals, such as histamine, can cause sneezing, itching, and irritation.
 
Allegra-D is a combination medication consisting of fexofenadine and pseudoephedrine. Fexofenadine (Allegra®) is part of a class of drugs called antihistamines. As the name implies, Allegra blocks the effects of histamine. This leads to the relief of allergy symptoms -- except for nasal congestion. Pseudoephedrine (the most common brand name being Sudafed®) is a decongestant. It works by decreasing the swelling in the nasal passages, which improves the nasal congestion.
 

Allegra-D Effects

Prior to the Allegra-D's approval in the United States, one clinical study was conducted on 651 adults and adolescents. In this study, people taking Allegra-D had improved allergy relief compared to the group of people not taking the medicine. This improvement was measured based on a symptom score that looked at changes in the following allergy symptoms:
 
  • Sneezing
  • Runny nose
  • Itchy nose and/or throat
  • Itchy, watery, and/or red eyes
  • Nasal congestion.
     

Allegra-D: When and How Do I Take It?

Some general considerations for when and how to take Allegra-D include:
 
  • Allegra-D comes in a tablet form. It is recommended that you take your Allegra-D dose on an empty stomach with a glass of water.
     
  • Taking Allegra-D with food should be avoided.
     
  • Do not break, chew, or crush the Allegra-D tablets.
     
  • Allegra-D should be taken at the same time each day to help maintain an even level of medicine in the blood. Do not take it more often than directed.
     
  • Allegra-D 12 Hour is usually taken twice a day. Allegra-D 24 Hour is usually taken once a day.
     
  • Occasionally, the inactive components of Allegra-D may be eliminated in the feces looking very similar to the tablet.
     
  • For Allegra-D to work properly, you have to take it as prescribed. Allegra-D will not work if you stop taking it.
     

Allegra-D Dosing

The dose of Allegra-D that your healthcare provider recommends will vary depending on a number of factors, including:
 
  • The type of Allegra-D
  • Other medical conditions you may have
  • Other medication you may be currently taking.
     
As is always the case, do not adjust your dose unless your healthcare provider specifically instructs you to do so.
 
(Click Allegra-D Dosage for more information about dosing for Allegra-D in both adults and adolescents.)
 

Side Effects of Allegra-D

(The Allegra-D side effects listed below are NOT a complete list of possible side effects of Allegra-D. Your healthcare provider can discuss a more complete list of Allegra-D side effects with you.)
 
As with any medicine, there are possible side effects with Allegra-D. Yet, not everyone who takes Allegra-D will experience side effects. In fact, most people tolerate it well. When side effects do occur, in most cases they are minor, meaning they require no treatment or are easily treated by you or your healthcare provider.
 
Based on clinical studies, the most common side effects with Allegra-D were:
 
(Click Allegra-D Side Effects to learn more about these and other side effects with Allegra-D.)
 

Drug Interactions With Allegra-D

There are several medications that may potentially interact with Allegra-D.
 
(Click Allegra-D Drug Interactions for more information about Allegra-D and these other medicines.)
 

Allegra-D: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider before taking Allegra-D if you have:
 
Let your healthcare provider know if you:
 
  • Are pregnant or thinking about becoming pregnant
  • Are breastfeeding
  • Have any allergies, including allergies to Allegra-D, Allegra, Sudafed, or adrenergic medicines.
     
Also, tell your healthcare provider about all other medicines you may be taking, including prescription and non-prescription medicines, antacids, vitamins, and herbal supplements.
 
Finally, make sure to contact your healthcare provider or call an ambulance immediately if you experience any breathing or swallowing difficulty.
 
(Click Allegra-D Precautions and Warnings for more information on this topic, including information on who should not take Allegra-D.)
 

Allegra-D Overdose

If you happen to overdose on Allegra-D, seek medical attention immediately. Allegra-D overdose symptoms may include:
 
  • Dizziness
  • Dry mouth
  • Drowsiness.
     

Allegra-D Storage Methods

All Allegra-D should be stored at room temperature, away from moisture.
 
Keep Allegra-D and all medications out of the reach of children.
 

Allegra-D: What Should I Do If I Miss a Dose?

If you forget to take a dose of Allegra-D, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and continue with your normal dosing schedule. Never double your dose of Allegra-D at one time.
 

Allegra-D Strengths

There are several strengths of Allegra-D available, including
 
  • Allegra-D 12 Hour (fexofenadine 60 mg and pseudoephedrine hydrochloride 120 mg)
  • Allegra-D 24 Hour (fexofenadine 180 mg and pseudoephedrine hydrochloride 240 mg).
     

Generic Allegra-D

There is currently no generic Allegra-D or over-the-counter Allegra-D available for sale.
 
(Click Generic Allegra-D for more information, including when a generic Allegra-D medicine is expected to become available.)
 
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;