You can take Actifed with or without food. If the medication bothers your stomach, try taking it with a little food. Actifed could make you either drowsy or more awake. If you find that it makes you drowsy, it may be best to take it at night. If you find that it keeps you awake, you may want to take Actifed during the day. For the medication to work properly, it must be taken as directed. If you are unsure of the directions for Actifed, talk with your doctor, nurse, or pharmacist.
(Click Actifed Dosage for more information on directions for Actifed Cold & Allergy. This article also offers some tips on when and how to effectively take this medication.)